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These effects are considered to be related to histamine release, since they are partially antagonized by pyrilamine, an antihistamine.

The touch of a bedsheet or the sensation of a passing breeze on an affected joint can provoke excruciating pain for people suffering with gout.

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Gout gout A metabolic disorder characterised by increased uric acid in the blood and joints, resulting in recurring painful arthritis and renal dysfunction with deposits of uric acid in the urinary tract, which in some cases is caused by either of two X-linked enzymes.

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Soybean intake rise plasma urate significantly.

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Febuxostat (Uloric) and allopurinol (Zyloprim) are equally effective in preventing recurrent gout.

It should be noted that NSAIDs, particularly aspirin, as well as other salicylate drugs, reduce the effectiveness of uricosurics, so they should be avoided if possible by patients taking them.

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